Ano and Kato Ktimeni lie in the municipality of Tamassi. Historically, Ktimeni was the capital of the ancient kingdom of Dolopas. Within the village district at the site of Paleokastro are remains of Mycenaean walls (1300 BC), and at Kastri, Mycenaean tombs have been found.
The Church of Zoodochos Pigi (Source of Life) in Fanari was built atop an ancient Roman bath.
Pefkofito, meaning Planted Pine is a beautiful village at 730 metres altitude within the Mouzaki region. At the site of Palea Theotokos, archaeological excavations have revealed the foundations of older temples with mosaic floors.
Loutropigi is located in a gorge a few kilometres above the Baths of Smokovo. The route to the village is historic as it starts from the ancient kingdom of the Dolopians, Menelaida. Segments of an ancient wall (Kastro) are found 4km north of the village at the site of Profitis Elias at an altitude of 995 metres.
The area of Katafili village was called Selipiana, taken from the name of the kingdom of Selipos which existed there in 285 B.C. The area abounds in archaeological ruins and artefacts, including walls which date from the Hellenistic period, coins, residences, graves, and statues.
Anavra is a village within the municipality of Tamassi, and is 28 km from Karditsa. Ancient graves have been found in the area testifying to its long history of continual occupation.
Leontari (pronounced Leondari) is in the municipality of Tamasi. The name of the village is taken from that of King Leontio, who, according to ancient history, ruled the region and was the brother-in-law to the King of Rendina, Menelaus. Ancient walls of the Dolopons can be found at the border of the village.
Moschato is in the Plastiras municipality and is16 kilometres from Karditsa, located at an altitude of 450 metres. Near the village is the Cave of Andrea the Thief of Limeri. Surely there are legends surrounding this cave.
In Loxada, there are Byzantine baths, which have yet to be excavated in full.
The village of Apidia Village in the Kallifoni area (23 km from Karditsa and 11 km from the village of Kallifoni) lies on of 330 metres. Ancient box-shaped graves have been found in the Apidia district that link it with habitation in antiquity.